Study reveals breast cancer triggers

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A UNIVERSITY of Adelaide study found mechanical pressure helps early breast cancer cells grow and spread. Cells use a sensor called PIEZO1 to detect pressure, triggering pathways that increase growth and aggressiveness and create lasting “mechanical memory.” Blocking these pathways reduced tumour progression. High PIEZO1 levels are linked to poorer outcomes, highlighting pressure as a key cancer driver and a promising target for new treatments and early intervention strategies.

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